Genetic Insights Into Depression Induced by Tuberculosis via Mediating Roles of Interleukins: Evidence From Mendelian Randomization
Interleukin-1R2 may mediate depressive symptoms in tuberculosis patients, potentially through specific inhibition of interleukin-1-related inflammatory signalling. These findings elucidate genetic mechanisms underlying tuberculosis-depression comorbidity and suggest novel targets for preventive and therapeutic interventions.
Authors
- Xiangmin Liu (ORCID: https://orcid.org/0000-0003-3154-4660)
- Weijin Huang (ORCID: https://orcid.org/0000-0002-4246-8889)
- Xue Qiu
- Huanhuan Li (ORCID: https://orcid.org/0000-0001-6462-5577)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Chengdu Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Tropical Medicine & International Health
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1111/tmi.70039
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00