Detection of anti-IH and transient adult anti-i in infectious mononucleosis potentially masking other red blood cell alloantibodies

This report highlights that benign cold antibodies can often be a nuisance in the investigation of RBC alloantibodies. Prewarming techniques must be used to eliminate these interferences and discrepancies, while titration of these cold agglutinins at different temperatures can help differentiate them.