Toll‐Like Receptor Polymorphisms Influence Graft‐Versus‐Host Disease and Infection Risk After Single‐Unit Cord Blood Transplantation for Adults
Our findings demonstrate that recipient and donor polymorphisms in TLR3, TLR5, and TLR9 genes affect GVHD development and infection risk following single-unit CBT in adults. Understanding these genetic influences may guide personalized approaches to improve CBT outcomes.
Authors
- Kazuaki Yokoyama (ORCID: https://orcid.org/0000-0003-2407-5368)
- Junya Kuroda (ORCID: https://orcid.org/0000-0001-6130-1550)
- Satoshi Takahashi (ORCID: https://orcid.org/0000-0002-0889-5449)
- Shohei Andoh
- Maki Monna‐Oiwa
- Yasuhito Nannya (ORCID: https://orcid.org/0000-0002-6526-0992)
- Megumi Hamatani‐Asakura
- Kaori Kondo
- Seiko Kato
- Hirona Ichimura
Institutions
- Tokyo Medical University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- European Journal Of Haematology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1111/ejh.70039
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00