Efficacy of Contractility Modulation Therapy in Patients with Transthyretin Amyloid Cardiomyopathy, Mildly Reduced to Reduced EF and NYHA III and IV: A Multicentric, Prospective Pilot Study for AMY-CCM Registry
This pilot study suggests that CCM therapy is a feasible and potentially effective option for ATTR-CM patients with advanced HF who are not candidates for existing disease-modifying treatments. These findings support the rationale for larger studies, including the ongoing AMY-CCM registry (NCT05167799), to validate CCM's therapeutic role in this population.
Authors
- Antonio Bisignani (ORCID: https://orcid.org/0000-0003-3938-4948)
- L Mazzocchetti
- Margherita Cannillo
- Matteo Ruzzolini (ORCID: https://orcid.org/0000-0002-0319-2621)
- Cristina Chimenti (ORCID: https://orcid.org/0000-0001-5954-3796)
- Daniele Masarone (ORCID: https://orcid.org/0000-0002-6781-7424)
- R Magnano
- Paolo Garrone (ORCID: https://orcid.org/0000-0002-5199-9155)
- Stefano Guarracini
- Procolo Marchese (ORCID: https://orcid.org/0000-0002-2677-9214)
- Luigi Cocchiara (ORCID: https://orcid.org/0009-0002-6604-1756)
- Francesca Gennaro
- Matteo Bianco (ORCID: https://orcid.org/0000-0002-6751-6437)
- Mauro Biffi (ORCID: https://orcid.org/0000-0003-4590-8584)
- Walter Grosso Marra (ORCID: https://orcid.org/0000-0003-4554-1110)
- Matteo Ziacchi (ORCID: https://orcid.org/0000-0003-3617-2739)
- Giovanni Mazzotta
- Carlo Lavalle
- Pierfrancesco Grossi
- Massimo Di Marco (ORCID: https://orcid.org/0000-0002-4423-5202)
Institutions
- Agostino Gemelli University Polyclinic (IT)
- Ospedale di Santo Spirito (IT)
- Ospedale Civile Di Ivrea (IT)
- Azienda Sanitaria Locale di Asti (IT)
- Azienda USL di Bologna (IT)
- Casa di cura Pierangeli (IT)
- Ospedale Monaldi (IT)
- Ospedale San Giuseppe (IT)
- Ospedale San Luigi Gonzaga (IT)
- University of Naples Federico II (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Journal of Cardiovascular Development and Disease
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3390/jcdd12100380
- Citations
- 1
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.81