Integrated single-cell transcriptomics and Mendelian randomization identify neutrophil-associated biomarker genes in colorectal cancer
Our study highlights PRDX1 and FTH1 as neutrophil-associated genes causally linked to CRC, offering promising targets for future immunotherapeutic strategies.
Authors
- Bing Yang (ORCID: https://orcid.org/0000-0002-0408-4518)
- Bin Guo (ORCID: https://orcid.org/0000-0003-3296-9177)
- Wenyu Wu (ORCID: https://orcid.org/0000-0003-1803-3006)
- Hongting Yan
- Yingjie Li (ORCID: https://orcid.org/0009-0004-1499-4613)
- Dongxin Tang (ORCID: https://orcid.org/0000-0003-0400-5549)
- Wenqi Huang (ORCID: https://orcid.org/0000-0002-0155-5409)
Institutions
- Guiyang College of Traditional Chinese Medicine (CN)
- Guizhou University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- TCM-Intigrated Cancer Center of Southern Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1007/s12672-025-03452-9
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Guizhou University