Phylogenetics and selective pressure analysis of human papillomavirus types 31 and 33 variants in Eastern China
Our study revealed two substitutions-A862T (Q97L) and G7064A (S491S)-associated with cervical lesions, along with eleven sites under positive selection. This work provides new insights into the clinical characteristics of HPV31/33 genetic variations and offers novel perspectives for developing next-generation vaccines in Eastern China.
Authors
- Yu Sun (ORCID: https://orcid.org/0000-0003-4269-7187)
- Xingyue Liu (ORCID: https://orcid.org/0000-0002-9168-0659)
- Tianyi Bi (ORCID: https://orcid.org/0009-0005-5161-7400)
- Fang Chen (ORCID: https://orcid.org/0000-0001-7149-5360)
- Qi Zhou (ORCID: https://orcid.org/0000-0002-6598-6486)
- Jiayin Mo
- Yingxin Gong (ORCID: https://orcid.org/0000-0002-7824-3905)
- Lin Lin (ORCID: https://orcid.org/0009-0008-8181-8758)
- Feifei Zhang (ORCID: https://orcid.org/0009-0009-3980-3672)
- Yaping Wang (ORCID: https://orcid.org/0000-0002-8432-2124)
- Zhiyong Wu (ORCID: https://orcid.org/0000-0002-6527-5502)
- Congjian Xu (ORCID: https://orcid.org/0000-0001-5692-5641)
- Yanyun Li (ORCID: https://orcid.org/0000-0001-6882-1284)
- Na He (ORCID: https://orcid.org/0000-0002-1571-0748)
- Yan Wang (ORCID: https://orcid.org/0009-0004-0741-2873)
- Wenjie Qu (ORCID: https://orcid.org/0009-0006-2907-008X)
- Wenqian Shi
Institutions
- Fudan University (CN)
- Shanghai Public Health Clinical Center (CN)
- Guangzhou Development Zone Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1186/s12879-025-11489-y
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China