Identification of immunosuppressive CD4+ T-cell subtype and construction of prognostic model for hepatocellular carcinoma
Our findings establish SPP1<sup>+</sup>TNFRSF18<sup>+</sup> CD4<sup>+</sup> T cells as central regulators of HCC immune suppression, offering novel strategies to enhance HCC immunotherapy.
Authors
- Yuqing Lou (ORCID: https://orcid.org/0000-0001-9218-2718)
- Lianchi Li
- Lan Zhang (ORCID: https://orcid.org/0000-0002-7572-1035)
- Feifei Tian (ORCID: https://orcid.org/0000-0002-1414-1838)
- Taoyou Zhou
- Chuxuan Wang (ORCID: https://orcid.org/0000-0002-3759-9542)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Southwest Jiaotong University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1007/s12672-025-03556-2
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00