Pulmonary calcified nodules and cysts as the initial presentation of Sjögren’s syndrome secondary nodular pulmonary amyloidosis: a rare case report

Pulmonary amyloidosis is a rare pulmonary manifestation of SS, especially with atypical early clinical symptoms, which can render diagnosis challenging. This case highlights that amyloidosis diagnosis precedes SS diagnosis. Moreover, it aims to alert clinicians that when multiple calcified nodules and cystic lesions are observed on chest CT, secondary pulmonary amyloidosis should be considered, and further investigations into related diseases such as SS should be conducted to avoid missed diagnoses.

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Publication Details

Journal
BMC Pulmonary Medicine
Published
2025-09-25
DOI
https://doi.org/10.1186/s12890-025-03876-7
Primary Topic
Amyloidosis: Diagnosis, Treatment, Outcomes
Type
article
Field-Weighted Citation Impact
0.00

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article

Pulmonary calcified nodules and cysts as the initial presentation of Sjögren’s syndrome secondary nodular pulmonary amyloidosis: a rare case report

Xiyan Zhu, Zhang Chao-ying, Zhi Fang, Yingming Jin
BMC Pulmonary Medicine
Amyloidosis: Diagnosis, Treatment, Outcomes
article

Pulmonary calcified nodules and cysts as the initial presentation of Sjögren’s syndrome secondary nodular pulmonary amyloidosis: a rare case report

Xiyan Zhu, Zhang Chao-ying, Zhi Fang, Yingming Jin
article en

Abstract

Pulmonary amyloidosis is a rare pulmonary manifestation of SS, especially with atypical early clinical symptoms, which can render diagnosis challenging. This case highlights that amyloidosis diagnosis precedes SS diagnosis. Moreover, it aims to alert clinicians that when multiple calcified nodules and cystic lesions are observed on chest CT, secondary pulmonary amyloidosis should be considered, and further investigations into related diseases such as SS should be conducted to avoid missed diagnoses.

BMC Pulmonary MedicineVol. 25(1)
Ningbo No. 2 Hospital (CN), Ningbo No.6 Hospital (CN)
Zhejiang Medical Association
Openalex Percentile: Top 77%
Amyloidosis: Diagnosis, Treatment, Outcomes
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