HBx promotes podocyte-macrophage transdifferentiation by mediating NLRP3 expression in hepatitis B virus-associated glomerulonephritis
These findings indicate that HBx triggers NLRP3 upregulation in podocytes and activates PMT. Thereafter, podocytes may function as antigen-presenting cells (APCs), consequently stimulating immune cell activation and resulting in inflammation cascades and renal fibrosis associated with HBV-GN.
Authors
- Haochen Guan (ORCID: https://orcid.org/0000-0003-1476-8371)
- Yitong Yang (ORCID: https://orcid.org/0000-0003-3127-2626)
- Zuhua He (ORCID: https://orcid.org/0000-0002-6098-7893)
- Yanhua Zhu
- Yuchao Niu
Institutions
- Qingdao University (CN)
- University of Science and Technology of China (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1186/s12985-025-02926-0
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fudan University
- Huashan Hospital