Multi-omics analysis reveals disrupted gut microbiota and metabolism in gastric cancer patients with high SIRI
High SIRI levels are associated with poorer prognosis in GC patients. Significant differences in gut microbiota and metabolites were observed across different SIRI levels in GC patients, showing their potential as non-invasive markers for GC risk stratification based on SIRI levels.
Authors
- Kailin Cai
- D Chen
- Fuwei Mao
- Yinghao Cao (ORCID: https://orcid.org/0000-0002-4825-1402)
- Mian Chen (ORCID: https://orcid.org/0000-0003-2342-4861)
- Cheng Wang (ORCID: https://orcid.org/0000-0002-1834-2119)
- Bo Liu (ORCID: https://orcid.org/0000-0003-3900-9486)
- Shenghe Deng (ORCID: https://orcid.org/0000-0001-6184-1389)
- Junnan Gu (ORCID: https://orcid.org/0000-0003-4828-6514)
- Falong Zou (ORCID: https://orcid.org/0009-0007-7189-6077)
Institutions
- Union Hospital (HK)
- National University of Singapore (SG)
- Wuhan Union Hospital (CN)
- Union Hospital (CN)
- Clinical Nutrition Research Centre (SG)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1186/s12885-025-14852-z
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00