In-depth investigation of the mechanism in rats with alcoholic acute pancreatitis via DNA methylation, intestinal flora, and fecal metabolomics
HIF-1α-25_CpG_35 methylation, intestinal flora, and metabolites involved in regulating AP pathogenesis. Methanobrevibacter_A, Ruminococcus_C_59129, Lactobacillus, Eubacterium_Q, Phascolarctobacterium_A, Homocysteine, Aspartic acid, Agmatine, 6-Ketoprostaglandin e1, Stearic acid, and Palmitic acid were the potential biomarkers, offering new insights into the pathogenesis of AP.
Authors
- Shifeng Zhu (ORCID: https://orcid.org/0000-0001-6017-6209)
- Weixing Ying
- Haicheng Dong
Institutions
- Tongde Hospital of Zhejiang Province (CN)
- Children's Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Journal of Inflammation
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1186/s12950-025-00463-9
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China