NCAPH-YAP1 interaction promotes breast cancer stemness and tumor progression
This study identifies NCAPH as a novel oncogenic factor in BC. NCAPH interacts with YAP1, promoting its nuclear translocation and enhancing BCSC traits and malignancy. Critically, YAP1 inhibition reverses NCAPH-driven effects, validating the NCAPH as a promising therapeutic target.
Authors
- Jiehua Li (ORCID: https://orcid.org/0000-0003-1499-0175)
- Caixin Qiu (ORCID: https://orcid.org/0009-0003-3394-7890)
- Yansha Wei
Institutions
- Guangxi Medical University (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1186/s13287-025-04648-0
- Citations
- 1
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Natural Science Foundation of Guangxi Province