A STAT1-GBP1 axis modulates epithelial proliferation in postpartum breast tissue by repressing CDKI expression
These findings identify a STAT1-GBP1 axis that enhances postpartum epithelial proliferation by repressing CDKI expression. This mechanism may help to explain the heightened vulnerability observed after childbirth and highlights potential biomarkers or early intervention targets in postpartum breast tissues.
Authors
- Laura M. Pacheco-Spann (ORCID: https://orcid.org/0000-0002-6531-8840)
- Amanda Arnold
- Stacey J. Winham (ORCID: https://orcid.org/0000-0002-8492-9102)
- Derek C. Radisky (ORCID: https://orcid.org/0000-0002-1962-8784)
- Sarah A. McLaughlin (ORCID: https://orcid.org/0000-0003-2170-9812)
- Nicole Cruz-Reyes (ORCID: https://orcid.org/0000-0002-7511-6169)
- Sharoon Akhtar (ORCID: https://orcid.org/0000-0003-3428-3769)
- Joshua Ogony
- Mark E. Sherman
- Amy C. Degnim
- Jennifer Vanessa Cabezas
- Savanna Touré
- P. W. Westerman
- Camila Pacheco Erak
Institutions
- Mayo Clinic (US)
- Jacksonville College (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1186/s13058-025-02117-3
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Cancer Institute