SUV39H1 facilitate the osteogenic differentiation of dental pulp stem cells by modulating lipid metabolism and mitochondrial dynamics through FASN via non-histone methylation and ubiquitination mechanism
Overall, SUV39H1 facilitated the osteogenic differentiation of DPSCs by modulating lipid metabolism and affected mitochondrial energy metabolism through FASN via non-histone methylation and ubiquitination mechanisms. The expression of SUV39H1was regulated by miR-4788.
Authors
- Dengsheng Xia (ORCID: https://orcid.org/0000-0002-9340-421X)
- Wanqing Wang (ORCID: https://orcid.org/0000-0002-3090-3388)
- Mengyuan Zhu (ORCID: https://orcid.org/0000-0001-8863-7142)
- Huina Liu (ORCID: https://orcid.org/0000-0002-0722-7158)
- Yangyang Cao (ORCID: https://orcid.org/0000-0001-7935-6170)
- Chen Zhang (ORCID: https://orcid.org/0000-0001-8576-818X)
- Ning Wang (ORCID: https://orcid.org/0000-0001-7531-7385)
- Xiao Han (ORCID: https://orcid.org/0000-0002-2952-6431)
Institutions
- Capital Medical University (CN)
- Shanghai Stomatological Hospital (CN)
- Cells Therapy (Poland) (PL)
- Beijing Shijitan Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1186/s13287-025-04657-z
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Capital Medical University