Human milk-derived 5′-UMP promotes thermogenesis and mitochondrial biogenesis to ameliorate obesity
Maternal obesity is associated with changes in the human milk metabolome. 5'-UMP, a nucleotide metabolite enriched in human milk, promotes thermogenesis and mitochondrial activation, effectively ameliorating obesity in zebrafish and human adipocytes. These findings support its potential as a safe, milk-derived therapeutic candidate for pediatric obesity intervention.
Authors
- Xirong Guo (ORCID: https://orcid.org/0000-0003-4873-8832)
- Juan Du (ORCID: https://orcid.org/0000-0001-5083-9435)
- Siqi Huang (ORCID: https://orcid.org/0000-0002-0403-4203)
- Haixia Hu (ORCID: https://orcid.org/0000-0003-1308-5739)
- Ling Zhang
- Zhou Peng (ORCID: https://orcid.org/0000-0003-3612-0912)
- Jianfang Gao
- Caiyu Lin
Institutions
- Shanghai Jiao Tong University (CN)
- Tongren Hospital (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fnut.2025.1661778
- Citations
- 1
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 1.12
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China