An Unusual Presentation of T-cell/Histiocyte-Rich B-cell Lymphoma: A Diagnostic Challenge

Necrotizing masses pose a remarkable diagnostic challenge as they masquerade as infections, ischemic events, malignancies, autoimmune conditions, etc. Herewith, we are discussing a rare presentation of a man in his early 40s who presented with a necrotizing mass in the anterior chest wall and underwent multiple evaluations resulting in several initial misdiagnoses before the definitive diagnosis of T-cell/histiocyte-rich B-cell lymphoma was made. The patient was initiated on the R-CHOP (rituximab, cyclophosphamide, Doxorubicin, Vincristine, and prednisone) regimen and is currently under therapy. This case report highlights the significance of the diagnostic approach with thorough histopathological and immunohistochemical evaluation to diagnose unusual presentations, for appropriate management, and improving patient outcomes.