Chronic stress-induced downregulation of MFN1 contributes to fatty liver in chickens
This study reveals a key mechanism by which chronic stress impairs mitochondrial fusion via GR-mediated suppression of MFN1, driving fatty liver development in broilers. These findings underscore the critical role of MFN1 in mitochondrial dynamics and lipid metabolism, offering novel insights for potential therapeutic strategies against fatty liver disease in poultry.
Authors
- David C.H. Yang (ORCID: https://orcid.org/0000-0003-2657-745X)
- Huimin Chen (ORCID: https://orcid.org/0000-0002-2079-873X)
- Xiaoyu Wang (ORCID: https://orcid.org/0000-0002-4665-5024)
- Jie Liu (ORCID: https://orcid.org/0000-0002-4187-0323)
- Ziting Guan (ORCID: https://orcid.org/0009-0007-3708-2221)
- Lei Wu (ORCID: https://orcid.org/0000-0002-2600-6342)
- Hui Yu (ORCID: https://orcid.org/0000-0003-1308-4832)
- Ke Zhang (ORCID: https://orcid.org/0000-0001-5972-5127)
- Ruqian Zhao
- Mindie Zhao
Institutions
- Oklahoma State University (US)
- Nanjing Agricultural University (CN)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fvets.2025.1646921
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province