EP4/ANXA2 axis in pulmonary arterial hypertension: therapeutic implications
This study reveals a crucial pathway involving EP4 and ANXA2 in PAH development and progression. Targeting EP4 and its downstream effector ANXA2 represents promising therapeutic strategies for PAH management.
Authors
- Hu Xu (ORCID: https://orcid.org/0000-0003-1198-0932)
- Zhiyu Dai (ORCID: https://orcid.org/0000-0002-2945-7923)
- Youfei Guan (ORCID: https://orcid.org/0000-0002-5231-0209)
- Xiuhui Mao
- Weijing Yun (ORCID: https://orcid.org/0000-0002-8711-0231)
- Qi Zheng
- Jiaming Xiu
- Chunxiu Du (ORCID: https://orcid.org/0000-0003-4152-4663)
- Bo Liang (ORCID: https://orcid.org/0000-0002-1749-6976)
- Hui Tang (ORCID: https://orcid.org/0000-0002-3384-8046)
- Hua Shao (ORCID: https://orcid.org/0000-0002-6206-921X)
- Qing Liang (ORCID: https://orcid.org/0000-0003-0916-416X)
- Lan Ye (ORCID: https://orcid.org/0000-0003-3735-5844)
- Wen Su (ORCID: https://orcid.org/0000-0001-5576-1286)
- Yali Wang (ORCID: https://orcid.org/0000-0002-2948-3400)
- Xiaoyan Zhang (ORCID: https://orcid.org/0000-0002-4060-2423)
- Chunhua Zhu (ORCID: https://orcid.org/0000-0001-6136-2150)
- Lihong Chen (ORCID: https://orcid.org/0000-0001-6370-1865)
- Jiayao Zhang (ORCID: https://orcid.org/0000-0002-9694-7404)
- Xiaowan Sun
- Ruqiang Yuan
- Chenglong Luo (ORCID: https://orcid.org/0000-0002-8309-3841)
- Fenling Fan (ORCID: https://orcid.org/0000-0002-7732-7701)
Institutions
- Fujian Medical University (CN)
- Longyan University (CN)
- Dalian Medical University (CN)
- Washington University in St. Louis (US)
- First Affiliated Hospital of Fujian Medical University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Shenzhen University Health Science Center (CN)
- East China Normal University (CN)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1093/eurheartj/ehaf763
- Citations
- 4
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.07