Co-occurring functional neurological disorder and autism: an exploratory study of comorbidities in a retrospective cohort study using TriNetX

This study presents the largest dataset to date characterising individuals with co-occurring FND and autism. Findings are consistent with previous findings of higher rates of autism in people with FND and reveal a potentially distinct clinical profile, marked by elevated rates of ADHD and psychiatric comorbidities, and increased occurrence of functional seizures compared to FND- or Autism-only groups. Recognising this overlap may improve diagnosis, clinical care, and understanding of mechanisms underlying the co-occurrence of FND and autism.

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Publication Details

Journal
Journal of Neurology
Published
2025-09-25
DOI
https://doi.org/10.1007/s00415-025-13385-6
Citations
4
Primary Topic
Autism Spectrum Disorder Research
Type
article
Field-Weighted Citation Impact
5.72
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article

Co-occurring functional neurological disorder and autism: an exploratory study of comorbidities in a retrospective cohort study using TriNetX

Timothy R. Nicholson, Francesca Happé, Mark John Edwards, Lee D. Smythe et al.
4 citations
Journal of Neurology
Autism Spectrum Disorder Research
5.72
article

Co-occurring functional neurological disorder and autism: an exploratory study of comorbidities in a retrospective cohort study using TriNetX

Timothy R. Nicholson, Francesca Happé, Mark John Edwards, Lee D. Smythe, Livia Asan
article en
4 citations

Abstract

This study presents the largest dataset to date characterising individuals with co-occurring FND and autism. Findings are consistent with previous findings of higher rates of autism in people with FND and reveal a potentially distinct clinical profile, marked by elevated rates of ADHD and psychiatric comorbidities, and increased occurrence of functional seizures compared to FND- or Autism-only groups. Recognising this overlap may improve diagnosis, clinical care, and understanding of mechanisms underlying the co-occurrence of FND and autism.

Journal of NeurologyVol. 272(10)
King's College London (GB), South London and Maudsley NHS Foundation Trust (GB), Essen University Hospital (DE), University of Duisburg-Essen (DE)
Openalex Percentile: Top 4%
Autism Spectrum Disorder Research
5.72
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Co-occurring functional neurological disorder and autism: an exploratory study of comorbidities in a retrospective cohort study using TriNetX — Timothy R. Nicholson, Francesca Happé, et al. · Journal of Neurology (2025) | TGRS Research Map | TGRS