Endothelial responses to angiogenic modulators highlight metabolic mechanisms underlying vascular dysfunction in preeclampsia
These correlations and in vitro changes suggest a mechanistic link between sFlt-1/PlGF ratios, oxidative stress-related damage, and metabolic reprogramming in ECs, which could be targeted for therapeutics. Furthermore, the identification of succinate and glycine as key metabolites associated with sFlt-1 levels and sFlt-1/PlGF ratios may provide novel biomarkers for disease risk stratification and/or monitoring PE progression.
Authors
- Ralf Bruder
- Priscila Rezeck Nunes
- Valéria C. Sandrim (ORCID: https://orcid.org/0000-0002-6168-7470)
- Ljubica Tasić (ORCID: https://orcid.org/0000-0003-2930-7332)
- Marco G. Alves (ORCID: https://orcid.org/0000-0001-7635-783X)
- Patrícia C. Braga (ORCID: https://orcid.org/0000-0002-3813-8107)
- Fábio Rogério de Moraes (ORCID: https://orcid.org/0000-0002-0425-0352)
- Irene Rebelo
- Raquel L. Bernardino (ORCID: https://orcid.org/0000-0002-1941-6634)
- Ricardo de Carvalho Cavalli (ORCID: https://orcid.org/0000-0001-5010-4914)
- Margarida Fardilha (ORCID: https://orcid.org/0000-0001-7459-9173)
- Pedro F. Oliveira (ORCID: https://orcid.org/0000-0002-4989-5699)
- Julyane N. S. Kaihara (ORCID: https://orcid.org/0000-0003-4881-8488)
Institutions
- Universidade de Ribeirão Preto (BR)
- Universidade de São Paulo (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Universidade do Porto (PT)
- Rede de Química e Tecnologia (PT)
- University of Aveiro (PT)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Placenta
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1016/j.placenta.2025.09.018
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.06