Actinomycetoquinones A–E, Anthraquinone-γ-Pyrones Discovered from Marine-Derived <i>Actinomycetospora</i> sp. Bacterium
Facilitated by LC-MS-PCA metabolomics methods and effective molecular networking for strain prioritization and dereplication, five new anthraquinone-γ-pyrones, actinomycetoquinones A-E (<b>1</b>-<b>5</b>), were isolated from a marine-derived <i>Actinomycetospora</i> sp. bacterium. The structures of <b>1</b>-<b>5</b> were elucidated by analysis of their HRMS and NMR spectroscopic data. The absolute configuration of <b>1</b> was unequivocally determined by single-crystal X-ray diffraction analysis using Cu Kα radiation. Actinomycetoquinone C exhibited antibacterial activity against methicillin-resistant <i>S. aureus</i> (MRSA) and <i>E. coli</i> with MIC values of 1 and 4 μg/mL, respectively.
Authors
- Zachary Bennett (ORCID: https://orcid.org/0000-0001-5407-1523)
- Gene E. Ananiev
- Ilia A. Guzei (ORCID: https://orcid.org/0000-0003-1976-7386)
- Scott R. Rajski (ORCID: https://orcid.org/0000-0002-0238-8411)
- Tae Hyun Lee (ORCID: https://orcid.org/0000-0003-0010-972X)
- Shaurya Chanana (ORCID: https://orcid.org/0000-0002-3021-2210)
- Song Guo (ORCID: https://orcid.org/0000-0001-9172-0799)
- Tim S. Bugni (ORCID: https://orcid.org/0000-0002-4502-3084)
- Thomas C. Brunold (ORCID: https://orcid.org/0000-0001-6516-598X)
- Fan Zhang (ORCID: https://orcid.org/0000-0001-9732-1123)
- Christopher D. Roberts (ORCID: https://orcid.org/0000-0003-0949-1320)
- Doug R. Braun (ORCID: https://orcid.org/0000-0002-4504-7035)
Institutions
- University of Wisconsin–Madison (US)
- University of Wisconsin Carbone Cancer Center (US)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1021/acs.jnatprod.5c00578
- Citations
- 1
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.39