Piperine targets SOAT1 to inhibit the progression of esophageal squamous cell carcinoma via ferroptosis
This study is the first to demonstrate that piperine targets SOAT1 to enhance ferroptosis by inhibiting the PI3K-AKT axis and upregulating the expression of KLF4/ALOX12B. This study strongly emphasizes the potential of piperine as a promising clinical therapeutic candidate for ESCC.
Authors
- Caibiao Wei (ORCID: https://orcid.org/0009-0007-5564-7695)
- Chengming Wei
- Wei Li (ORCID: https://orcid.org/0000-0003-1144-518X)
- Meina Shi
Institutions
- Macau University of Science and Technology (MO)
- Guangxi University (CN)
- Queen Mary Hospital (CN)
- Guangdong Food and Drug Vocational College (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1016/j.phymed.2025.157332
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04