Ziftomenib in Relapsed or Refractory <i>NPM1</i> -Mutated AML
Ziftomenib demonstrated significant clinical benefit and deep responses in patients with heavily pretreated, relapsed/refractory <i>NPM1</i>-m AML. Ziftomenib was well tolerated with a safety profile consistent with previous studies, including manageable differentiation syndrome, lack of clinically significant QTc prolongation, and low rates of myelosuppression.
Authors
- Mahmoud Elsawy (ORCID: https://orcid.org/0000-0001-9872-2471)
- Arnaud Pigneux (ORCID: https://orcid.org/0000-0001-5479-0261)
- Pau Montesinos (ORCID: https://orcid.org/0000-0002-3275-5593)
- James McCloskey
- Lionel Adès (ORCID: https://orcid.org/0000-0002-9020-8766)
- Marcie Riches (ORCID: https://orcid.org/0000-0003-0257-0990)
- Mohamad Khawandanah (ORCID: https://orcid.org/0000-0002-6627-1933)
- Adolfo de la Fuente (ORCID: https://orcid.org/0000-0002-1324-5555)
- Gail J. Roboz (ORCID: https://orcid.org/0000-0002-0384-3658)
- Caterina Giannini
- Mithun Vinod Shah (ORCID: https://orcid.org/0000-0002-5359-336X)
- Pierre Péterlin (ORCID: https://orcid.org/0000-0001-5463-6686)
- Francesco Lanza (ORCID: https://orcid.org/0000-0002-5189-7167)
- Jessica K. Altman (ORCID: https://orcid.org/0000-0003-1987-1896)
- Adrian Schwarzer (ORCID: https://orcid.org/0000-0001-5684-2280)
- Amitava Mitra
- James M. Foran (ORCID: https://orcid.org/0000-0003-1673-1708)
- Daniel Corum
- Robert L. Redner (ORCID: https://orcid.org/0000-0002-2042-296X)
- Harris S. Soifer (ORCID: https://orcid.org/0009-0006-4351-1363)
- Cristina Papayannidis (ORCID: https://orcid.org/0000-0001-8705-8333)
- Maria R. Baer (ORCID: https://orcid.org/0000-0002-9499-1348)
- Harry Paul Erba (ORCID: https://orcid.org/0000-0003-1093-2189)
- Dries Deeren (ORCID: https://orcid.org/0000-0001-9599-2142)
- Frédéric Barabé (ORCID: https://orcid.org/0000-0003-0024-3611)
- Marilyn Tabachri
- Kristen Marie Pettit (ORCID: https://orcid.org/0009-0007-3536-4137)
- Eduardo Rodríguez‐Arbolí (ORCID: https://orcid.org/0000-0002-2237-6733)
- Teresa Bernal (ORCID: https://orcid.org/0000-0002-2338-513X)
- Amir T. Fathi (ORCID: https://orcid.org/0000-0002-5848-6221)
- Suresh Kumar Balasubramanian (ORCID: https://orcid.org/0000-0001-9044-1309)
- Yazan F. Madanat (ORCID: https://orcid.org/0000-0001-9573-2690)
- Jordi Esteve Reyner
- Agustín Penedo
- Zijing Zhang (ORCID: https://orcid.org/0000-0002-3990-1442)
- Florian Heinrich Heidel (ORCID: https://orcid.org/0000-0003-2438-1955)
- Mollie Leoni (ORCID: https://orcid.org/0000-0001-6585-7919)
- Adriano Venditti (ORCID: https://orcid.org/0000-0002-0245-0553)
Institutions
- Northwestern University (US)
- Universitat Autònoma de Barcelona (ES)
- University of Maryland, Baltimore (US)
- Roswell Park Comprehensive Cancer Center (US)
- Hackensack University Medical Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Harvard University (US)
- Wayne State University (US)
- Vanderbilt University (US)
- Cornell University (US)
- University of Michigan (US)
- Hotel Dieu Hospital (CA)
- Hôpital Maisonneuve-Rosemont (CA)
- Centre Hospitalier Universitaire de Lille (FR)
- Hospital Universitari i Politècnic La Fe (ES)
- Medizinische Hochschule Hannover (DE)
- Massachusetts General Hospital (US)
- Fred Hutch Cancer Center (US)
- The Barbara Ann Karmanos Cancer Institute (US)
- Hôpital Lyon Sud (FR)
- Istituto di Ematologia di Bologna (IT)
- Hôpital Cardiologique du Haut-Lévêque (FR)
- Mayo Clinic in Arizona (US)
- Duke Medical Center (US)
- Centre d'Investigation Clinique de Nantes (FR)
- UPMC Hillman Cancer Center (US)
- Instituto de Biomedicina de Sevilla (ES)
- University of Pittsburgh Medical Center (US)
- Hôpital Saint-Louis (FR)
- Mayo Clinic in Florida (US)
- Hospital Universitario Virgen del Rocío (ES)
- Kura Oncology (United States) (US)
- MD Anderson Cancer Center Madrid (ES)
- Banner MD Anderson Cancer Center
- U-M Rogel Cancer Center (US)
- Vanderbilt-Ingram Cancer Center
- Duke Cancer Institute
- University of Oklahoma Health Sciences Center (US)
- Universidad de Sevilla (ES)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1200/jco-25-01694
- Citations
- 11
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 19.47