Immune Characterization of Intracranial Aneurysms Using Noninvasive Endoluminal Biopsy With High-Dimensional Single-Cell Phenotyping
This study demonstrates that noninvasive endoluminal biopsy combined with high-dimensional single-cell immune phenotyping can identify distinct immune signatures in IAs. A shift toward neutrophil-dominant inflammation was associated with aneurysm growth and rupture. Limitations include the cross-sectional design, which limits causal inference. These findings may support future development of immune-based biomarkers and targeted immunomodulatory therapies to stabilize IAs and prevent rupture.
Authors
- Danielle Miyagishima (ORCID: https://orcid.org/0000-0003-3257-5469)
- Murat Günel (ORCID: https://orcid.org/0000-0002-2290-7055)
- Andrew B. Koo (ORCID: https://orcid.org/0000-0002-2854-649X)
- Brianna C. Theriault (ORCID: https://orcid.org/0000-0003-3907-3808)
- Tanyeri Barak (ORCID: https://orcid.org/0000-0002-8522-1552)
- Nana Adenu‐Mensah
- Joseph Haynes (ORCID: https://orcid.org/0000-0002-7134-2273)
- Paul Cedeno
- Ryan Hebert (ORCID: https://orcid.org/0000-0003-0492-6364)
- Nanthiya Sujijantarat (ORCID: https://orcid.org/0000-0002-5857-5718)
- Charles Matouk (ORCID: https://orcid.org/0000-0003-3234-9541)
- Kanat Yalcin (ORCID: https://orcid.org/0009-0009-7451-3179)
- Batur Gültekin (ORCID: https://orcid.org/0009-0002-9630-4967)
- Joseph Antonios (ORCID: https://orcid.org/0000-0002-3867-3337)
- Michele H. Johnson (ORCID: https://orcid.org/0000-0003-1820-4709)
Institutions
- Yale New Haven Hospital (US)
- Yale University (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1212/wnl.0000000000214185
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00