Blood Biomarker and Raman Analysis of Leukocytes in the Multicenter Intelligence Trials: At the Intensive Care Unit (Intelligence-1) and the Emergency Department (Intelligence-2)
In theory, Raman assessment of leukocytes might still be a promising tool for sepsis diagnosis and patient stratification, but there is more basic, translational, and clinical research needed to refine its usability and clinical role, probably also taking questions of the pathophysiology of the dysregulated host response for a phenotype stratification into account.
Authors
- Jürgen Popp (ORCID: https://orcid.org/0000-0003-4257-593X)
- Jan Rüger (ORCID: https://orcid.org/0000-0001-8583-1089)
- Evangelos J. Giamarellos‐Bourboulis (ORCID: https://orcid.org/0000-0003-4713-3911)
- Christos Mathas
- Oleg Ryabchykov (ORCID: https://orcid.org/0000-0002-4655-8080)
- Daniel Thomas‐Rüddel (ORCID: https://orcid.org/0000-0001-9143-8566)
- Johannes Winning
- Thomas Wilhelm Bocklitz (ORCID: https://orcid.org/0000-0003-2778-6624)
- Nikolaos Antonakos (ORCID: https://orcid.org/0000-0002-7552-5878)
- Stylianos Karatzas
- Michael Bauer (ORCID: https://orcid.org/0000-0002-2666-859X)
- Stamatios Chalvatzis
- Antigone Kotsaki (ORCID: https://orcid.org/0000-0002-6345-4021)
- Aikaterini Pistiki
- Anja Silge (ORCID: https://orcid.org/0000-0002-6262-6020)
- Ute Neugebauer
- Athanasios Prekates
- Florian Knorr
- Anuradha Ramoji (ORCID: https://orcid.org/0000-0003-2723-6614)
- Iwan W. Schie (ORCID: https://orcid.org/0000-0003-0336-3168)
- Natalie Arend
- Jesper Eugen‐Olsen (ORCID: https://orcid.org/0000-0002-4630-4275)
- Michael Kiehntopf
- Georgia Damoraki (ORCID: https://orcid.org/0000-0001-7986-7720)
- Konstantinos Toutouzas (ORCID: https://orcid.org/0000-0001-9099-1554)
- Kazi Sultana Farhana Azam
- Frank Bloos
Institutions
- Albert Einstein College of Medicine (US)
- Montefiore Medical Center (US)
- National and Kapodistrian University of Athens (GR)
- Amager Hospital (DK)
- Leibniz Institute of Photonic Technology (DE)
- Gentofte Hospital (DK)
- Ippokrateio General Hospital of Thessaloniki (GR)
- Tzaneion General Hospital (GR)
- Jena University Hospital (DE)
- Agia Olga Hospital (GR)
- Hippocration General Hospital (GR)
- Friedrich Schiller University Jena (DE)
Publication Details
- Journal
- Shock
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1097/shk.0000000000002699
- Primary Topic
- Spectroscopy Techniques in Biomedical and Chemical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00