Effects of Phenytoin on the Retinal Ganglion Cell-Inner Plexiform Layer in Acute Optic Neuritis
This study provides Class II evidence that compared with placebo, phenytoin is associated with greater preservation of the mGCIPL thickness in patients with acute demyelinating optic neuropathy.
Authors
- Ahmed Toosy (ORCID: https://orcid.org/0000-0002-4441-3750)
- Magnus Fugger
- Claudia A. M. Gandini Wheeler‐Kingshott (ORCID: https://orcid.org/0000-0002-4832-1300)
- Marios Yiannakas (ORCID: https://orcid.org/0000-0003-4986-446X)
- Ferrán Prados (ORCID: https://orcid.org/0000-0002-7872-0142)
- Martin Koltzenburg (ORCID: https://orcid.org/0000-0001-9181-5966)
- Srikirti Kodali (ORCID: https://orcid.org/0000-0003-2960-5655)
- Rebecca S. Samson (ORCID: https://orcid.org/0000-0002-0197-702X)
- Alessia Bianchi (ORCID: https://orcid.org/0000-0001-5541-5818)
- Rhian Raftopoulos
- Simon J. Hickman (ORCID: https://orcid.org/0000-0003-1003-4370)
- Marcello Moccia (ORCID: https://orcid.org/0000-0003-2613-3090)
- Raju Kapoor
- Anjaneya Prasad Malladi
Institutions
- Universitat Oberta de Catalunya (ES)
- Queen Mary University of London (GB)
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- King's College Hospital NHS Foundation Trust (GB)
- Federico II University Hospital (IT)
- University College London (GB)
- University of Palermo (IT)
Publication Details
- Journal
- Neurology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1212/wnl.0000000000213951
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bristol-Myers Squibb
- Sanofi
- Biogen
- Celgene
- Cleveland Clinic
- European Committee for Treatment and Research in Multiple Sclerosis
- National Brain Appeal
- National Institute for Health and Care Research
- Ataxia UK
- Multiple Sclerosis Society
- University College London
- Rosetrees Trust
- Ipsen
- MedDay Pharmaceuticals
- Ministero dell'Università e della Ricerca
- Medical Research Council