Serum amino acid levels are associated with brain hypometabolism in patients across the Alzheimer’s disease continuum
Our findings suggest that specific serum metabolites show differential associations with regional brain glucose hypometabolism in patients across the AD continuum. While these associations did not remain significant after correction for multiple testing, preliminary signals linking amino acid-related metabolites (e.g., hydroxyproline, aspartate, putrescine, glutamine, and ornithine) to brain metabolism highlight the potential role of metabolic pathways in AD pathophysiology. These results support the utility of metabolomics as a complementary approach for identifying early biomarkers of neurodegeneration.
Authors
- Sadri Sa'di
- Reza Nemati (ORCID: https://orcid.org/0000-0001-8155-8855)
- Haitham Salem (ORCID: https://orcid.org/0000-0002-1783-0217)
- Aileen Saranjam (ORCID: https://orcid.org/0000-0002-7573-2770)
- Mohammad D. Mansouri
- Mahsa Sadeghi (ORCID: https://orcid.org/0009-0002-3109-5543)
- Hamide Nasiri (ORCID: https://orcid.org/0009-0008-2361-3308)
- Kiana Orangi
- Masha Mayeli
- Fatemeh Esmizadeh
- Kiana Sattari
Institutions
- University of Rome Tor Vergata (IT)
- Zanjan University of Medical Sciences (IR)
- Iran University of Medical Sciences (IR)
- Mashhad University of Medical Sciences (IR)
- Allameh Tabataba'i University (IR)
- Islamic Azad University, Isfahan (IR)
- Islamic Azad University, Arak (IR)
- Yale University (US)
- Urmia University (IR)
- University of Isfahan (IR)
- Urmia University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- IBRO Neuroscience Reports
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1016/j.ibneur.2025.09.007
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00