TRIM49 Deficiency Stabilizes a Galectin-3/EGR1 Transcriptional Complex That Drives Invasiveness of Gastric Adenocarcinoma
A proinvasion galectin-3/EGR1 transcriptional complex is a therapeutic vulnerability in the highly invasive TRIM49-deficient gastric adenocarcinoma, which can be disrupted by the oral galectin-3 inhibitor GB1107 to prevent cancer spreading.
Authors
- Sen Yang (ORCID: https://orcid.org/0000-0003-3222-2268)
- Xiu‐Wu Bian (ORCID: https://orcid.org/0000-0003-4383-0197)
- Xianfeng Li (ORCID: https://orcid.org/0000-0002-8024-7980)
- Linrong Che
- Liting Shen
- Deshun Zeng
- Y Deng
- Zhaole Chu
- X Zhang
- Qingning Zhao
- Shuoran Tian
- Q. L. Liu (ORCID: https://orcid.org/0009-0002-3677-7738)
- Zhong‐yi Qin (ORCID: https://orcid.org/0000-0002-5504-9480)
- Liangzhi Wen (ORCID: https://orcid.org/0000-0001-9999-2422)
- Ning Li
- Jinyang Li (ORCID: https://orcid.org/0009-0000-6057-8937)
- Tao Wang (ORCID: https://orcid.org/0000-0003-4442-8829)
- Ke Li (ORCID: https://orcid.org/0000-0002-8571-7128)
- Jingyuan Li
- Chenhui Wang (ORCID: https://orcid.org/0000-0002-7527-4028)
- Bin Wang (ORCID: https://orcid.org/0000-0001-5574-1760)
- Xu Chen
- Dongfeng Chen (ORCID: https://orcid.org/0000-0003-1700-2195)
- Mengyi Han (ORCID: https://orcid.org/0009-0008-8642-6809)
- Xiangyu Du
- Shiyin Peng (ORCID: https://orcid.org/0000-0002-6484-0805)
- L.-Y. Wu
- Junyv Xiang
- Qiaoqiao Zhang (ORCID: https://orcid.org/0009-0001-0132-5398)
- Xiaohan Wang
- Min Mao (ORCID: https://orcid.org/0000-0001-9062-1676)
- Kewei Liu
- Hong Zhou
Institutions
- Army Medical University (CN)
- Chongqing University (CN)
- Sichuan University (CN)
- Chinese Mathematical Society (CN)
- Daping Hospital (CN)
- Zhejiang Police College (CN)
- Xinqiao Hospital (CN)
- Police General Hospital (TH)
- Southwest Hospital (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0252
- Citations
- 1
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.80