TRIM49 Deficiency Stabilizes a Galectin-3/EGR1 Transcriptional Complex That Drives Invasiveness of Gastric Adenocarcinoma

A proinvasion galectin-3/EGR1 transcriptional complex is a therapeutic vulnerability in the highly invasive TRIM49-deficient gastric adenocarcinoma, which can be disrupted by the oral galectin-3 inhibitor GB1107 to prevent cancer spreading.

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Publication Details

Journal
Cancer Research
Published
2025-09-25
DOI
https://doi.org/10.1158/0008-5472.can-25-0252
Citations
1
Primary Topic
Galectins and Cancer Biology
Type
article
Field-Weighted Citation Impact
0.80
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article

TRIM49 Deficiency Stabilizes a Galectin-3/EGR1 Transcriptional Complex That Drives Invasiveness of Gastric Adenocarcinoma

Sen Yang, Xiu‐Wu Bian, Xianfeng Li, Linrong Che et al.
1 citations
Cancer Research
Galectins and Cancer Biology
0.80
article

TRIM49 Deficiency Stabilizes a Galectin-3/EGR1 Transcriptional Complex That Drives Invasiveness of Gastric Adenocarcinoma

Sen Yang, Xiu‐Wu Bian, Xianfeng Li, Linrong Che, Liting Shen, Deshun Zeng, Y Deng, Zhaole Chu, X Zhang, Qingning Zhao, Shuoran Tian, Q. L. Liu, Zhong‐yi Qin, Liangzhi Wen, Ning Li, Jinyang Li, Tao Wang, Ke Li, Jingyuan Li, Chenhui Wang, Bin Wang, Xu Chen, Dongfeng Chen, Mengyi Han, Xiangyu Du, Shiyin Peng, L.-Y. Wu, Junyv Xiang, Qiaoqiao Zhang, Xiaohan Wang, Min Mao, Kewei Liu, Hong Zhou
article en
1 citations

Abstract

A proinvasion galectin-3/EGR1 transcriptional complex is a therapeutic vulnerability in the highly invasive TRIM49-deficient gastric adenocarcinoma, which can be disrupted by the oral galectin-3 inhibitor GB1107 to prevent cancer spreading.

Cancer ResearchVol. 86(2)
Army Medical University (CN), Chongqing University (CN), Sichuan University (CN), Chinese Mathematical Society (CN), Daping Hospital (CN), Zhejiang Police College (CN), Xinqiao Hospital (CN), Police General Hospital (TH), Southwest Hospital (CN)
Openalex Percentile: Top 23%
Galectins and Cancer Biology
0.80
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