Metabolomic Assessment of Low- Versus High-Volume Resuscitation in a Combined Porcine Model of Severe Burn and Traumatic Brain Injury
In this study, targeted metabolomics was used to identify plasma and urinary oxylipins and steroids in both the restrictive and aggressive resuscitation groups. Notably, significant elevations in 15 urinary oxylipins and three serum steroids were identified only in animals that were randomized to "restricted" resuscitation. These findings demonstrate detectable differences in lipid metabolites within 8 hours of severe injury, which may correlate with differences in inflammation and facilitate goal-directed resuscitation.
Authors
- Timothy M. Guenther (ORCID: https://orcid.org/0000-0002-0014-4974)
- Tina L. Palmieri (ORCID: https://orcid.org/0000-0001-6340-1715)
- Marguerite W. Spruce (ORCID: https://orcid.org/0000-0002-9464-7379)
- Carl A. Beyer (ORCID: https://orcid.org/0000-0002-9785-8526)
- Connor M. Caples
- Jeffrey Fine (ORCID: https://orcid.org/0000-0002-6396-9383)
- Frederick J. Meyers (ORCID: https://orcid.org/0000-0002-4456-4647)
- Linda M. Schutzman
- Sandra L. Taylor (ORCID: https://orcid.org/0000-0001-7811-812X)
- Oliver Fiehn (ORCID: https://orcid.org/0000-0002-6261-8928)
- Ian E. Brown
- J. Grayson
- Lindsay M Bach
Institutions
- David Grant USAF Medical Center (US)
- Shriners Hospitals for Children - Northern California (US)
- University of California, Davis (US)
Publication Details
- Journal
- Shock
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1097/shk.0000000000002719
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 0.00