Dysregulated mitochondrial energy metabolism drives the progression of mucosal field effects to invasive bladder cancer
Multiplatform mutational and gene expression profiling complemented with proteomic and metabolomic spatial mapping were used on the whole-organ scale to identify the molecular profile of bladder cancer evolution from field effects. Analysis of the mutational landscape identified three types of mutations, referred to as α, β, and γ. Time modeling of the mutations revealed that carcinogenesis may span 30 years and can be divided into dormant and progressive phases. The α mutations developed in the dormant phase. The progressive phase lasted 5 years and was signified by expanding β mutations, but it was driven to invasive cancer by γ mutations. The mutational landscape emerged on a background of disorganized urothelial differentiation, activated epithelial-mesenchymal transition, and enhanced immune infiltration with T-cell exhaustion. Complex dysregulation of mitochondrial energy metabolism with downregulation of oxidative phosphorylation emerged as the leading mechanism driving the progression of mucosal field effects to invasive cancer. © 2025 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Authors
- Neema Navai (ORCID: https://orcid.org/0000-0001-8457-3786)
- Colin P. Dinney (ORCID: https://orcid.org/0000-0002-8969-711X)
- Charles Chuanhai Guo (ORCID: https://orcid.org/0000-0003-2182-3287)
- Jiansong Chen (ORCID: https://orcid.org/0000-0002-7641-9268)
- Nagireddy Putluri (ORCID: https://orcid.org/0000-0003-4488-7400)
- Peng Wei (ORCID: https://orcid.org/0000-0001-7758-6116)
- Sangkyou Lee
- Paweł Kuś (ORCID: https://orcid.org/0000-0002-4367-9821)
- Sung Yun Jung (ORCID: https://orcid.org/0000-0003-1521-7977)
- Roman Jaksik (ORCID: https://orcid.org/0000-0003-1866-6380)
- Khanh N. Dinh (ORCID: https://orcid.org/0000-0002-0010-4251)
- David J. McConkey (ORCID: https://orcid.org/0000-0003-1971-0638)
- Bogdan Czerniak (ORCID: https://orcid.org/0000-0002-8289-9173)
- Marek Kimmel (ORCID: https://orcid.org/0000-0001-8161-890X)
- Richard R. Behringer (ORCID: https://orcid.org/0000-0001-7282-1543)
- Cathy Mendelsohn (ORCID: https://orcid.org/0000-0002-4026-4073)
- David Cogdell
- Yishan Wang (ORCID: https://orcid.org/0000-0002-9460-3608)
- Huiqin Chen (ORCID: https://orcid.org/0000-0003-2477-5436)
- Jolanta Bondaruk
- June Goo Lee
Institutions
- Silesian University of Technology (PL)
- The University of Texas MD Anderson Cancer Center (US)
- Johns Hopkins University (US)
- Baylor College of Medicine (US)
- Johns Hopkins Medicine (US)
- Cancer Genetics (United States) (US)
- Pediatrics and Genetics (US)
- Rice University (US)
- Columbia University (US)
Publication Details
- Journal
- The Journal of Pathology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1002/path.6474
- Citations
- 3
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.02