Diagnosis and management of multidrug resistant tuberculosis

Universal drug susceptibility testing is key for early diagnosis of drug resistant tuberculosis (TB) and should be offered to all people with bacteriologically confirmed TB; rapid molecular diagnostic tests used as an initial di(eagnostic investigation can simultaneously detect Mycobacterium tuberculosis and drug susceptibility early. Treatment of people with multidrug resistant TB or rifampicin resistant TB with shorter oral regimens based on bedaquiline results in improved treatment success with better tolerability.