Severe Japanese encephalitis of a pregnant woman in the first trimester of pregnancy: a case report

Pregnancy may have contributed to the pathogenesis of severe JE infection in this patient. The administration of the vaccines in high-risk women considering fertility may prolong protective cell-mediated immunity and maintain IgM response to protect from severe JE virus infection. The treatment of pregnant JE patients was symptomatic, and attention was given to the patient's nutritional status, acid balance and coagulation function. The incidence of secondary anti-NMDAR encephalitis in JE pregnant patients is also worthy of inquiry.