The distribution and the clinical importance of MUC5B and TERT variants in Turkish patients with idiopathic pulmonary fibrosis
Our findings indicate that the MUC5B rs35705950 variant is significantly associated with increased IPF susceptibility among Turkish patients. In contrast, the TERT rs2736100 variant was not linked to IPF risk. Additionally, the presence of the MUC5B rs35705950 variant correlated with later disease onset and relatively preserved pulmonary function in this patient population.
Authors
- Özden Altıok Clark (ORCID: https://orcid.org/0000-0002-8449-4620)
- Aliye Candan Öğüş (ORCID: https://orcid.org/0000-0001-9371-4288)
- Hülya Dirol
- Ömer Özbudak (ORCID: https://orcid.org/0000-0001-9516-8129)
- Aslı Toylu (ORCID: https://orcid.org/0000-0002-5531-6825)
- Ayşe Ödemiş (ORCID: https://orcid.org/0000-0003-3582-0415)
- Aykut Çilli (ORCID: https://orcid.org/0000-0001-9985-3502)
- Tülay Özdemir
Institutions
- Akdeniz University (TR)
Publication Details
- Journal
- BMC Pulmonary Medicine
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1186/s12890-025-03903-7
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Akdeniz Üniversitesi