Differential results of genetic risk scoring for multiple sclerosis in European and African American populations
A GRS for MS stratified European and Latino/admixed individuals but not African ancestry. Incorporating African-specific data enhanced performance, underscoring the need for more ancestry-tailored GRS.
Authors
- David A. Hafler (ORCID: https://orcid.org/0000-0003-4664-535X)
- Cyprien A. Rivier (ORCID: https://orcid.org/0000-0002-1148-1829)
- Erin E. Longbrake (ORCID: https://orcid.org/0000-0002-1179-3937)
- Guido J. Falcone (ORCID: https://orcid.org/0000-0002-6407-0302)
- Santiago Clocchiatti‐Tuozzo (ORCID: https://orcid.org/0000-0001-5377-434X)
- Lucila Ohno‐Machado (ORCID: https://orcid.org/0000-0002-8005-7327)
- Leqi Xu (ORCID: https://orcid.org/0000-0001-6789-4959)
- Hongyu Zhao (ORCID: https://orcid.org/0009-0004-0091-8281)
Institutions
- Yale University (US)
- Yale New Haven Health System (US)
Publication Details
- Journal
- Multiple Sclerosis Journal
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1177/13524585251377607
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47