Aerobic Oxidation of Imidazolines to 2-Arylimidazoles Using CuSO4∙H2O as a Catalyst
Abstract Imidazoles are considered the merit heterocyclic moiety in medicinal chemistry and drug design. Here, we report on a convenient method for the aerobic oxidation of imidazolines under mild conditions using the cheap and available CuSO4∙5H2O as the catalyst. The proposed method allows one to prepare 2-arylimidazoles bearing electron-donating and -withdrawing groups in good and quantitative yields. The developed procedure is applicable for the preparation of labile and oxidation-intolerant heterocyclic moieties.
Authors
- Natalia S. Soldatova (ORCID: https://orcid.org/0000-0002-1738-4747)
- Artem V. Semenov (ORCID: https://orcid.org/0000-0003-4647-7018)
- Sergey V. Baykov (ORCID: https://orcid.org/0000-0002-8912-5816)
- Mekhman S. Yusubov (ORCID: https://orcid.org/0000-0001-9233-1824)
- Павел Сергеевич Постников (ORCID: https://orcid.org/0000-0001-9713-1290)
- Matvey K. Shurikov (ORCID: https://orcid.org/0009-0008-4058-0878)
- Kristina A. Myachina
Institutions
- St Petersburg University (RU)
- National Research Tomsk State University (RU)
- Tomsk Polytechnic University (RU)
- Novosibirsk Institute of Organic Chemistry (RU)
- Saint-Petersburg Institute of History (RU)
Publication Details
- Journal
- Synthesis
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1055/a-2705-5409
- Primary Topic
- Synthesis and Biological Evaluation
- Type
- article
- Field-Weighted Citation Impact
- 0.00