Interobserver agreement and histologic analysis of atypical ductal hyperplasia bordering on ductal carcinoma in situ: A multi-institutional study
Breast pathologists demonstrated substantial agreement on individual histologic features but poor agreement on final diagnoses, likely due to differences in weighting histologic parameters. While lesion extent was frequently cited, it did not significantly differ between cases with and without carcinoma on excision. Instead, nuclear enlargement, necrosis, and spindle-shaped nuclei were significantly associated with carcinoma in subsequent excision. We propose that biopsy cases exhibiting a nuclear size more than 2-fold of background epithelial cells, necrosis, or spindle-shaped nuclei should be suggestive of DCIS.
Authors
- Shi Wei
- Huina Zhang (ORCID: https://orcid.org/0000-0002-4208-7680)
- Uma Krishnamurti (ORCID: https://orcid.org/0000-0001-5848-8748)
- Peter Podany
- Jing Du
- Di Ai (ORCID: https://orcid.org/0000-0003-2972-4582)
- Lorraine Colon-Cartagena
- Ujunwa Korie
- Hongxia Sun (ORCID: https://orcid.org/0000-0003-3229-4173)
- Yuanxin Liang (ORCID: https://orcid.org/0009-0004-1533-8984)
- Mohamed M. Kahila (ORCID: https://orcid.org/0000-0002-7446-6562)
- Haiying Zhan
Institutions
- Yale New Haven Hospital (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Rochester Medical Center (US)
- University of Alabama at Birmingham (US)
- Yale University (US)
- The University of Texas Health Science Center (US)
Publication Details
- Journal
- American Journal of Clinical Pathology
- Published
- 2025-07-25
- DOI
- https://doi.org/10.1093/ajcp/aqaf088
- Primary Topic
- Breast Lesions and Carcinomas
- Type
- article
- Field-Weighted Citation Impact
- 0.00