Determinants of de novo mutations in extended pedigrees of 43 dog breeds

The unique mutational landscape in canids is determined by paternal age, body size, and CpG Islands recombination. Despite extensive breeding, germline mutation rates in dogs remain stable across breeds. The elevated mutation rate in CpG Islands due to recombination in the absence of PRDM9 underscores a distinct evolutionary mechanism in canids. These findings enhance our understanding of mutation dynamics, with implications for canine genetic diversity, disease susceptibility, and broader genomic studies in species lacking PRDM9.

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Publication Details

Journal
Genome biology
Published
2025-09-25
DOI
https://doi.org/10.1186/s13059-025-03804-2
Citations
2
Primary Topic
Genomics and Phylogenetic Studies
Type
article
Field-Weighted Citation Impact
1.61

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article

Determinants of de novo mutations in extended pedigrees of 43 dog breeds

Hannes Lohi, Søren Besenbacher, Jilong Ma, Mikkel Heide Schierup et al.
2 citations
Genome biology
Genomics and Phylogenetic Studies
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article

Determinants of de novo mutations in extended pedigrees of 43 dog breeds

Hannes Lohi, Søren Besenbacher, Jilong Ma, Mikkel Heide Schierup, Meritxell Riera, Julia E. Niskanen, Elaine A. Ostrander, Tong Zhou, Marjo K. Hytönen, Sruthi Hundi, Guimei Li, Noora Salokorpi, Guodong Wang, Shaojie Zhang
article en
2 citations

Abstract

The unique mutational landscape in canids is determined by paternal age, body size, and CpG Islands recombination. Despite extensive breeding, germline mutation rates in dogs remain stable across breeds. The elevated mutation rate in CpG Islands due to recombination in the absence of PRDM9 underscores a distinct evolutionary mechanism in canids. These findings enhance our understanding of mutation dynamics, with implications for canine genetic diversity, disease susceptibility, and broader genomic studies in species lacking PRDM9.

Genome biologyVol. 26(1)
National Institutes of Health (US), University of Helsinki (FI), Kunming Institute of Botany (CN), Kunming Institute of Zoology (CN), Aarhus University (DK), Aarhus University Hospital (DK), National Human Genome Research Institute (US), Yunnan Animal Science and Veterinary Institute (CN), University of Chinese Academy of Sciences (CN), Folkhälsans Forskningscentrum (FI)
National Natural Science Foundation of China, Chinese Academy of Sciences, Jane ja Aatos Erkon Säätiö, Novo Nordisk, China Scholarship Council, Novo Nordisk Fonden, National Human Genome Research Institute
Openalex Percentile: Top 15%
Genomics and Phylogenetic Studies
1.61
DOIOpen Access PDFOpenAlex
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