Mesenchymal stem cell-derived extracellular vesicles exert Th1-mediated anti-inflammatory effects via miR-146a/NF-κB pathway: comparison with dupilumab in a mouse model of atopic dermatitis
MSC-EVs offer a novel cell-free therapy for AD, demonstrating comparable or superior efficacy to dupilumab, with broader immunomodulatory effects and the advantage of a single-dose administration.
Authors
- Doil Park (ORCID: https://orcid.org/0000-0002-7432-5487)
- Yongming Ji (ORCID: https://orcid.org/0000-0002-9581-1740)
- Joo Ho Kim (ORCID: https://orcid.org/0000-0003-2904-8780)
- Oh Young Bang (ORCID: https://orcid.org/0000-0002-7962-8751)
- Ji‐Eun Kim (ORCID: https://orcid.org/0000-0002-3643-2177)
- Hyoung‐Mo Yang (ORCID: https://orcid.org/0000-0003-3602-9772)
- Jae-Chern Yoo (ORCID: https://orcid.org/0000-0003-3721-0207)
Institutions
- Samsung (South Korea) (KR)
- Samsung Medical Center (KR)
- Biosolution (South Korea) (KR)
- Naver (South Korea) (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1186/s13287-025-04649-z
- Citations
- 4
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 8.02
Funders
- National Research Foundation
- Ministry of Science and ICT, South Korea