Soft Drink Consumption and Depression Mediated by Gut Microbiome Alterations
In this cohort study, it was found that soft drink consumption may contribute to MDD through gut microbiota alterations, notably involving Eggerthella. Public health strategies to reduce soft drink intake may help mitigate depression risk, especially among vulnerable populations; in addition, interventions for depression targeting the microbiome composition appear promising.
Authors
- Carmen Schiweck (ORCID: https://orcid.org/0000-0003-4215-0448)
- L. Fisch (ORCID: https://orcid.org/0000-0001-6424-7676)
- Corinna Bang (ORCID: https://orcid.org/0000-0001-6814-6151)
- Jae‐Hyun Lee (ORCID: https://orcid.org/0000-0002-0760-0071)
- Adèle H. Ribeiro (ORCID: https://orcid.org/0000-0002-4523-2062)
- Marius Welzel (ORCID: https://orcid.org/0000-0002-4946-2156)
- Robert Nitsch (ORCID: https://orcid.org/0000-0002-6885-2555)
- Susanne L. Meinert (ORCID: https://orcid.org/0000-0003-2177-7161)
- Sharmili Edwin Thanarajah (ORCID: https://orcid.org/0000-0003-3608-1474)
- Ramona Leenings
- Tim Hahn (ORCID: https://orcid.org/0000-0002-8929-4134)
- Andreas Lügering
- Nils R. Winter (ORCID: https://orcid.org/0000-0002-6241-1492)
- Jonathan Repple (ORCID: https://orcid.org/0000-0003-1379-9491)
- Aicha Bouzouina
- Jan Ernsting (ORCID: https://orcid.org/0000-0003-4649-2111)
- Benjamin Straube (ORCID: https://orcid.org/0000-0002-9837-0944)
- Florian Thomas‐Odenthal (ORCID: https://orcid.org/0000-0003-4912-8307)
- Nina Alexander (ORCID: https://orcid.org/0009-0002-7412-0163)
- Andreas Reif (ORCID: https://orcid.org/0000-0002-0992-634X)
- Silke Matura (ORCID: https://orcid.org/0000-0001-7666-9534)
- Igor Nenadić (ORCID: https://orcid.org/0000-0002-0749-7473)
- Dominik Heider (ORCID: https://orcid.org/0000-0002-3108-8311)
- Frederike Stein (ORCID: https://orcid.org/0000-0002-5052-6022)
- Sarah Kittel‐Schneider (ORCID: https://orcid.org/0000-0003-3057-6150)
- Mareike Aichholzer (ORCID: https://orcid.org/0000-0002-1291-3304)
- Paula Usemann (ORCID: https://orcid.org/0009-0005-4566-0058)
- Tilo T. J. Kircher (ORCID: https://orcid.org/0000-0002-2514-2625)
- Ruth Hanßen (ORCID: https://orcid.org/0000-0002-7283-9302)
- Carlotta Barkhau (ORCID: https://orcid.org/0000-0002-7546-9183)
- John F. Cryan (ORCID: https://orcid.org/0000-0001-5887-2723)
- Mirjam Bloemendaal (ORCID: https://orcid.org/0000-0001-5897-0649)
- Lea Teutenberg (ORCID: https://orcid.org/0009-0002-7783-8461)
- Rachel N. Lippert (ORCID: https://orcid.org/0000-0002-6905-2234)
- Leon Fehse
- Carmen Uckermark
- Udo Dannlowski
- Hamidreza Jamalabadi
- Maximilian Konowski (ORCID: https://orcid.org/0009-0009-2790-9330)
- Andre Franke
Institutions
- Goethe University Frankfurt (DE)
- Harvard University (US)
- Philipps University of Marburg (DE)
- Justus-Liebig-Universität Gießen (DE)
- University of Münster (DE)
- University College Cork (IE)
- Christian-Albrechts-Universität zu Kiel (DE)
- Fraunhofer Institute for Translational Medicine and Pharmacology (DE)
- Center for Digestive and Liver Diseases (US)
- Max Planck Institute for Metabolism Research (DE)
- Brain (Germany) (DE)
- Universitätsklinikum Würzburg (DE)
- University Hospital Frankfurt (DE)
- APC Microbiome Institute (IE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- University Hospital Cologne (DE)
- German Center for Diabetes Research (DE)
- German Institute of Human Nutrition (DE)
- Heinrich Heine University Düsseldorf (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Bethel University (US)
Publication Details
- Journal
- JAMA Psychiatry
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1001/jamapsychiatry.2025.2579
- Citations
- 5
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 4.03