Circulating ketone bodies and risk of incident atrial fibrillation: insights from the MESA and UK Biobank cohorts
Higher concentrations of KB are associated with an increased risk of AF in predominantly healthy, community-based cohorts, acknowledging that many participants also had comorbidities such as hypertension and diabetes, particularly among smokers. Ketone bodies could serve as a potential biomarker for identifying populations at risk for AF.
Authors
- Margery A. Connelly (ORCID: https://orcid.org/0000-0002-3917-592X)
- Parveen K. Garg (ORCID: https://orcid.org/0000-0002-6482-2711)
- Rishi Rikhi (ORCID: https://orcid.org/0000-0002-8013-4564)
- James McParland (ORCID: https://orcid.org/0000-0003-1318-0461)
- Vardhmaan Jain (ORCID: https://orcid.org/0000-0001-7265-380X)
- Michael D. Shapiro (ORCID: https://orcid.org/0000-0002-9071-3287)
- Ambarish Pandey (ORCID: https://orcid.org/0000-0001-9651-3836)
- Jorge R. Kizer (ORCID: https://orcid.org/0000-0001-9936-7803)
- Kenneth J. Mukamal (ORCID: https://orcid.org/0000-0001-8450-6970)
- Christopher L. Schaich (ORCID: https://orcid.org/0000-0002-5302-0828)
- Sadiya S. Khan (ORCID: https://orcid.org/0000-0003-0643-1859)
- Parag Anilkumar Chevli (ORCID: https://orcid.org/0000-0002-4084-8175)
- Susan R. Heckbert
Institutions
- Northwestern University (US)
- University of Southern California (US)
- Beth Israel Deaconess Medical Center (US)
- University of California, San Francisco (US)
- University of Washington (US)
- LabCorp (United States) (US)
- Northwestern University (PH)
- Woodruff Health Sciences Center (US)
- Wake Forest University (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- European Journal of Preventive Cardiology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1093/eurjpc/zwaf543
- Citations
- 2
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 2.33