Glutathione attenuates sepsis-associated encephalopathy via dual modulation of NF-κB and PKA/CREB pathways
This study provides the first evidence of GSH's dual mechanism action in SAE, establishing it as a promising multi-target therapeutic candidate. These findings open new avenues for developing effective SAE interventions targeting both inflammatory and neuroprotective pathways.
Authors
- Hui Lü (ORCID: https://orcid.org/0000-0002-5921-1043)
- Yong Liu (ORCID: https://orcid.org/0000-0003-1738-7857)
- Cailin Wang (ORCID: https://orcid.org/0000-0001-7708-5362)
- Xiangru Wen
Institutions
- Xuzhou Medical College (CN)
- Suzhou Municipal Hospital (CN)
- Suzhou Traditional Chinese Medicine Hospital (CN)
- The Fifth People’s Hospital of Suzhou (CN)
Publication Details
- Journal
- Open Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1515/med-2025-1282
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00