Shear stress-induced endothelial HEG1 signalling regulates vascular tone and blood pressure
Our study identifies a novel shear-sensitive endothelial HEG1 signalling pathway in BP regulation, providing potential therapeutic targets for hypertension.
Authors
- Christian Trautwein (ORCID: https://orcid.org/0000-0003-2762-8247)
- Xiaohui Chen (ORCID: https://orcid.org/0000-0002-1864-6729)
- Muredach P. Reilly (ORCID: https://orcid.org/0000-0002-3035-9386)
- Kai Markus Schneider (ORCID: https://orcid.org/0000-0002-0047-3794)
- Carolin Victoria Schneider (ORCID: https://orcid.org/0000-0002-6728-9246)
- Xiaoli Chen (ORCID: https://orcid.org/0000-0001-7327-4860)
- Jie Liu (ORCID: https://orcid.org/0000-0002-9476-1833)
- Wenrun Wu (ORCID: https://orcid.org/0000-0001-7781-406X)
- Xiangjian Zheng (ORCID: https://orcid.org/0000-0001-6277-5168)
- Pengxiong Zhu (ORCID: https://orcid.org/0000-0003-2224-5079)
- Jinnan Yue (ORCID: https://orcid.org/0009-0006-8303-3191)
- Xiuxiang Liu (ORCID: https://orcid.org/0000-0002-2918-5390)
- Lin Zhang (ORCID: https://orcid.org/0000-0003-1961-7812)
- Qi Zhang (ORCID: https://orcid.org/0000-0002-8935-8396)
- Yuzhen Zhang (ORCID: https://orcid.org/0000-0002-9570-1269)
- Junping Liu (ORCID: https://orcid.org/0000-0001-7442-2116)
- Fang Ji
- Liang Zheng (ORCID: https://orcid.org/0000-0002-2113-0117)
- Jianfei Xu (ORCID: https://orcid.org/0000-0002-7890-3264)
- Pingjin Gao (ORCID: https://orcid.org/0000-0002-7750-3314)
- Jie Pi (ORCID: https://orcid.org/0000-0002-9825-1398)
Institutions
- Shanghai Jiao Tong University (CN)
- TU Dortmund University (DE)
- Ruijin Hospital (CN)
- Universitätsklinikum Aachen (DE)
- Shanghai East Hospital (CN)
- Shanghai Institute of Hypertension (CN)
- University Hospital Carl Gustav Carus (DE)
- Leibniz Research Centre for Working Environment and Human Factors (DE)
- Tianjin Medical University (CN)
- Technische Universität Dresden (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1093/eurheartj/ehaf742
- Citations
- 4
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.22