Shear stress-induced endothelial HEG1 signalling regulates vascular tone and blood pressure

Our study identifies a novel shear-sensitive endothelial HEG1 signalling pathway in BP regulation, providing potential therapeutic targets for hypertension.

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Publication Details

Journal
European Heart Journal
Published
2025-09-23
DOI
https://doi.org/10.1093/eurheartj/ehaf742
Citations
4
Primary Topic
Angiogenesis and VEGF in Cancer
Type
article
Field-Weighted Citation Impact
3.22
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article

Shear stress-induced endothelial HEG1 signalling regulates vascular tone and blood pressure

Christian Trautwein, Xiaohui Chen, Muredach P. Reilly, Kai Markus Schneider et al.
4 citations
European Heart Journal
Angiogenesis and VEGF in Cancer
3.22
article

Shear stress-induced endothelial HEG1 signalling regulates vascular tone and blood pressure

Christian Trautwein, Xiaohui Chen, Muredach P. Reilly, Kai Markus Schneider, Carolin Victoria Schneider, Xiaoli Chen, Jie Liu, Wenrun Wu, Xiangjian Zheng, Pengxiong Zhu, Jinnan Yue, Xiuxiang Liu, Lin Zhang, Qi Zhang, Yuzhen Zhang, Junping Liu, Fang Ji, Liang Zheng, Jianfei Xu, Pingjin Gao, Jie Pi
article en
4 citations

Abstract

Our study identifies a novel shear-sensitive endothelial HEG1 signalling pathway in BP regulation, providing potential therapeutic targets for hypertension.

European Heart Journal
Shanghai Jiao Tong University (CN), TU Dortmund University (DE), Ruijin Hospital (CN), Universitätsklinikum Aachen (DE), Shanghai East Hospital (CN), Shanghai Institute of Hypertension (CN), University Hospital Carl Gustav Carus (DE), Leibniz Research Centre for Working Environment and Human Factors (DE), Tianjin Medical University (CN), Technische Universität Dresden (DE), RWTH Aachen University (DE)
Openalex Percentile: Top 8%
Angiogenesis and VEGF in Cancer
3.22
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