Implication for Clinical Trials From Longitudinal Tau-PET Accumulation Across Biological Alzheimer Disease Stages
Stage-specific patterns of tau-PET change highlighted the importance of baseline biological AD staging for selecting outcome regions of interest. Statistical power analyses indicated that aligning outcome regions with disease stage reduced sample size estimates, suggesting potential gains in trial efficiency. While findings were consistent across 2 independent cohorts, differences in tracers and demographic composition represent key limitations.
Authors
- Chris Hsiao (ORCID: https://orcid.org/0009-0009-2062-3516)
- Serge Gauthier (ORCID: https://orcid.org/0000-0003-4272-3330)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Joseph Therriault (ORCID: https://orcid.org/0000-0002-7826-4781)
- Paolo Vitali (ORCID: https://orcid.org/0000-0001-8953-1542)
- Jean‐Paul Soucy (ORCID: https://orcid.org/0000-0001-6979-1259)
- Jaime Fernández Arias (ORCID: https://orcid.org/0000-0002-6810-5920)
- Nesrine Rahmouni (ORCID: https://orcid.org/0009-0004-3081-8468)
- Pâmela C.L. Ferreira (ORCID: https://orcid.org/0000-0003-2134-9829)
- Arthur C. Macedo (ORCID: https://orcid.org/0000-0002-3957-0284)
- Stijn Servaes (ORCID: https://orcid.org/0000-0002-4431-957X)
- Tevy Chan (ORCID: https://orcid.org/0009-0001-9134-5949)
- Brandon J. Hall (ORCID: https://orcid.org/0009-0007-4578-2033)
- Seyyed Ali Hosseini (ORCID: https://orcid.org/0000-0001-7542-7541)
- Bruna Bellaver (ORCID: https://orcid.org/0000-0002-2212-3373)
- Yi‐Ting Wang (ORCID: https://orcid.org/0000-0002-9130-5461)
- Robert Hopewell (ORCID: https://orcid.org/0000-0002-2478-5872)
- Yansheng Zheng
- Étienne Aumont (ORCID: https://orcid.org/0000-0002-8997-7090)
- Gleb Bezgin (ORCID: https://orcid.org/0000-0002-1069-9201)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Lydia Trudel (ORCID: https://orcid.org/0009-0002-5593-7717)
Institutions
- Montreal Neurological Institute and Hospital (CA)
- University of Pittsburgh (US)
- Imaging, Brain, and Neuropsychiatry (FR)
- McGill University (CA)
Publication Details
- Journal
- Neurology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1212/wnl.0000000000214111
- Citations
- 1
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36