Identification and functional validation of kynureninases from oral bacteria
This study demonstrates KynU activity in oral bacteria, revealing an unrecognised aspect of microbial metabolism with potential implications for host-microbe interactions. Further investigation is required to elucidate the biological significance of bacterial KYN metabolites and their role in oral diseases.
Authors
- J. B. S. Coulter (ORCID: https://orcid.org/0000-0002-6328-7702)
- Halah Ahmed (ORCID: https://orcid.org/0000-0002-2121-0811)
- Alex Charlton (ORCID: https://orcid.org/0000-0001-8501-648X)
- Vsevolod Telezhkin (ORCID: https://orcid.org/0000-0002-5054-8774)
- Chien‐Yi Chang (ORCID: https://orcid.org/0000-0003-3570-4019)
- Pisit Charoenwongwatthana (ORCID: https://orcid.org/0000-0002-6633-4877)
- Mark D Gidley
Institutions
- Mahidol University (TH)
- Newcastle Dental Hospital (GB)
- University of Newcastle Australia (AU)
- Newcastle University (GB)
Publication Details
- Journal
- Journal of Oral Microbiology
- Published
- 2025-09-21
- DOI
- https://doi.org/10.1080/20002297.2025.2561213
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00