Oral microbial signatures underlying recurrence via PI3K/AKT/mTOR pathway modulation in oral squamous cell carcinoma
Oral saliva microbiome profiling reveals distinct microbial patterns associated with OSCC recurrence. Our correlation-based functional predictions indicated that the enrichment of <i>Eubacterium</i> and <i>Lactobacillus</i> along with a lower abundance of <i>Veillonella</i> may influence recurrence through oncogenic PI3K/AKT/mTOR, underscoring the prognostic potential of saliva-based microbial biomarkers.
Authors
- Joo Yong Park (ORCID: https://orcid.org/0000-0002-0969-151X)
- Sung Weon Choi (ORCID: https://orcid.org/0000-0002-2038-2881)
- Suk Min Youn (ORCID: https://orcid.org/0000-0002-0910-3028)
- Jae Hee Ko (ORCID: https://orcid.org/0000-0002-5130-3066)
- Chong Woo Yoo (ORCID: https://orcid.org/0000-0002-5221-4516)
- Zeba Praveen (ORCID: https://orcid.org/0009-0001-4980-6684)
- Yeon-Hee Kim (ORCID: https://orcid.org/0000-0003-4036-4661)
- Jong-Ho Lee (ORCID: https://orcid.org/0000-0002-8843-545X)
- Mi Kyung Kim (ORCID: https://orcid.org/0000-0001-5279-4162)
Institutions
- National Cancer Center (US)
- National Cancer Center (KR)
- Cancer Clinic (US)
Publication Details
- Journal
- Journal of Oral Microbiology
- Published
- 2025-09-20
- DOI
- https://doi.org/10.1080/20002297.2025.2560020
- Citations
- 1
- Primary Topic
- Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.05