Integrating ctDNA Dynamics and Sequential Organoid Drug Screening Enhances Breast Cancer Treatment Efficacy
Monitoring circulating tumor DNA in combination with drug screening of organoids enables dynamic, personalized breast cancer therapy adjustments to overcome resistance and improve treatment efficacy.
Authors
- Xiaping Miao
- Jun Tian
- Yuanyuan Yu (ORCID: https://orcid.org/0000-0003-0943-2267)
- Yanni Song
- Abiyasi Nanding (ORCID: https://orcid.org/0000-0002-8343-0721)
- Yuhuan Meng (ORCID: https://orcid.org/0000-0001-7464-3103)
- Yanbo Chen (ORCID: https://orcid.org/0009-0001-5762-336X)
- Y Q Zhang (ORCID: https://orcid.org/0009-0008-3573-414X)
- Xingda Zhang (ORCID: https://orcid.org/0000-0001-5823-8490)
- Da Pang (ORCID: https://orcid.org/0000-0003-2853-4170)
- Shouping Xu (ORCID: https://orcid.org/0000-0001-6154-3381)
- Weiguang Yuan
- Tao Chen (ORCID: https://orcid.org/0000-0002-2147-709X)
- Fang Fang (ORCID: https://orcid.org/0009-0008-7815-6589)
- Guoqiang Zhang (ORCID: https://orcid.org/0000-0003-0771-7533)
- Siwei Li (ORCID: https://orcid.org/0009-0005-6642-9859)
- Wenhui Hao
- Dalin Li (ORCID: https://orcid.org/0000-0002-6474-5998)
- Shihui Yu (ORCID: https://orcid.org/0000-0003-3672-4732)
- Xianyu Zhang (ORCID: https://orcid.org/0000-0002-9738-2361)
- Hui Li
- Jialin Liu (ORCID: https://orcid.org/0000-0001-8578-9028)
- Jing An (ORCID: https://orcid.org/0000-0002-1265-2474)
- Yongdong Jiang (ORCID: https://orcid.org/0000-0003-3160-0757)
- Yajie Gong (ORCID: https://orcid.org/0009-0005-7434-9349)
- Ji Wang (ORCID: https://orcid.org/0000-0002-4660-7727)
- Song Chen
- Shilu Zhao
- Wei Tan
Institutions
- Harbin Medical University (CN)
- Yuhuangding Hospital (CN)
- Heilongjiang Academy of Sciences (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Kingmed Diagnostics (CN)
- Shanghai Huayi Group (China) (CN)
- Dahua Technology (China) (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0608
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.94