Adiposity distribution and risks of 12 obesity-related cancers: a Mendelian randomization analysis
Our analyses provide novel insights into the relationship between adiposity distribution and cancer risk. These insights highlight the potential importance of adipose tissue distribution alongside maintaining a healthy weight for cancer prevention.
Authors
- James Yarmolinsky (ORCID: https://orcid.org/0000-0003-4371-0873)
- Andrea Gsur (ORCID: https://orcid.org/0000-0002-9795-1528)
- Tom G. Richardson (ORCID: https://orcid.org/0000-0002-7918-2040)
- Matthew A. Lee (ORCID: https://orcid.org/0000-0001-6262-3447)
- Benjamin Schuster‐Böckler (ORCID: https://orcid.org/0000-0002-8892-5133)
- Ľudmila Vodičková (ORCID: https://orcid.org/0000-0002-8277-539X)
- Daniel D. Buchanan (ORCID: https://orcid.org/0000-0003-2225-6675)
- Nicholas J. Timpson (ORCID: https://orcid.org/0000-0002-7141-9189)
- Neil Murphy (ORCID: https://orcid.org/0000-0003-3347-8249)
- Stephen B. Gruber (ORCID: https://orcid.org/0000-0001-8656-7822)
- Lucy J. Goudswaard (ORCID: https://orcid.org/0000-0003-1481-6871)
- Marc J. Gunter (ORCID: https://orcid.org/0000-0001-5472-6761)
- Hermann Brenner (ORCID: https://orcid.org/0000-0002-6129-1572)
- Dimitri J. Pournaras (ORCID: https://orcid.org/0000-0001-8798-920X)
- Heinz Freisling (ORCID: https://orcid.org/0000-0001-8648-4998)
- Emma E. Vincent (ORCID: https://orcid.org/0000-0002-8917-7384)
- Emma Hazelwood (ORCID: https://orcid.org/0000-0002-4888-6037)
- Robert C. Grant (ORCID: https://orcid.org/0000-0002-9821-0377)
- Marina Vabistsevits (ORCID: https://orcid.org/0000-0003-1121-6790)
- Niloy Jewel Samadder (ORCID: https://orcid.org/0009-0003-9740-9696)
- Li Li (ORCID: https://orcid.org/0000-0003-1802-9517)
Institutions
- City Of Hope National Medical Center (US)
- North Bristol NHS Trust (GB)
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- German Cancer Research Center (DE)
- Charles University (CZ)
- Heidelberg University (DE)
- University of Exeter (GB)
- Princess Margaret Cancer Centre (CA)
- University of Bristol (GB)
- Comprehensive Cancer Center Vienna (AT)
- Ludwig Cancer Research (GB)
- National Center for Tumor Diseases (DE)
- Mayo Clinic Hospital (US)
- NIHR Exeter Clinical Research Facility (GB)
- Center for Cancer Research (US)
- MRC Epidemiology Unit (GB)
- Centre international de recherche sur le cancer (FR)
- Imperial College London (GB)
- University of Virginia (US)
- Medical University of Vienna (AT)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1093/jnci/djaf201
- Citations
- 2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.63
Funders
- Pfizer
- AstraZeneca
- World Health Organization
- Genome Canada
- World Cancer Research Fund International
- Incyte
- Government of Canada
- Cancer Research UK
- Royal College of Surgeons of England
- European Commission
- University of Bristol
- Eisai
- Novo Nordisk
- Institut National Du Cancer
- Agentura Pro Zdravotnický Výzkum České Republiky
- Ipsen
- National Institutes of Health
- Horizon 2020 Framework Programme
- Canadian Institutes of Health Research
- Medical Research Council
- World Cancer Research Fund
- National Cancer Institute