Proteomics-based risk prediction and drug targets identification for chronic obstructive pulmonary disease
Protein biomarkers outperform genetic risk scores and complement clinical factors for COPD prediction, with a streamlined 10-protein panel offering clinical feasibility. The study identifies novel pathways and causal therapeutic targets. Further validation is needed prior to routine clinical implementation.
Authors
- Xiaoqin Gan (ORCID: https://orcid.org/0009-0002-1906-666X)
- Xianhui Qin (ORCID: https://orcid.org/0000-0001-7812-7982)
- Yiting Wu (ORCID: https://orcid.org/0000-0001-8079-9497)
- Ziliang Ye (ORCID: https://orcid.org/0000-0002-8626-4925)
- Sisi Yang (ORCID: https://orcid.org/0009-0008-2696-9107)
- Yuanyuan Zhang (ORCID: https://orcid.org/0000-0002-9894-248X)
- Yiwei Zhang (ORCID: https://orcid.org/0000-0001-9611-9337)
- Yanjun Zhang (ORCID: https://orcid.org/0000-0003-2176-6657)
- Hao Xiang (ORCID: https://orcid.org/0000-0003-0902-0115)
- Yu Huang (ORCID: https://orcid.org/0000-0001-5355-0047)
Institutions
- Nanfang Hospital (CN)
- National Clinical Research (US)
- Southern Medical University (CN)
Publication Details
- Journal
- Thorax
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1136/thorax-2024-222397
- Citations
- 2
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 3.04