Temporal trends indicate an epidemiological shift in the pathology of mesial temporal lobe epilepsy

Trends of changing etiologies as well as altering clinical and neuropsychological features of patients with mTLE suggest an epidemiological shift over the past decades. Overlapping distributions of fading early-onset classic mTLE-AHS and an increasing influx of late-onset sLE fit the clinical observations and demand retrospective follow-up studies in other countries/regions to disentangle triggering factors. Prospective studies should investigate temporal trends in autoantibody subgroups of patients with sLE.