Salbutamol in mild asthmatic exacerbations in children. Three is not better than one

Authors´ conclusions: the bronchodilator effect of a single inhaled dose of short action beta agonists with a valve holding chamber is similar to the administration of successive doses in children with mild acute asthma exacerbation. Reviewers´commentary: this study in children with mild asthmatic exacerbations, after a first effective dose of salbutamol, finds no short-term functional benefit in administering successive doses. There is no evidence in the longer-term impact or in other clinical variables. There is no data about the effect in more severe exacerbations neither in patients with partial response to a first dose of bronchodilator.